When your franchise player(s) occupy positions that take violent contact every snap they are targeted on, e.g. RBs, there is no such thing as being too careful IMO. Gurley got one series in against Kansas City to help shake off rust and test out how the knee feels now over a year post-op. He looked amazing and also scored a TD. No need to see any more of him until the games start for real.
I also would not let Goff take any more snaps behind your 2nd string o-line. He's taking too many hits. The protection just isn't good enough. Particularly from Williams.
Every first team player already nursing an injury after last night (e.g. Robinson, Gaines, Brockers) I'd also sit for the final pre-season game.